GW-1100

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Chemical Structure| 306974-70-9 同义名 : -
CAS号 : 306974-70-9
货号 : A756645
分子式 : C27H25FN4O4S
纯度 : 97%
分子量 : 520.58
MDL号 : MFCD09953714
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(96.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 GW1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 or linoleic acid with a pIC50 value equal to 5.99.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.92mL

0.38mL

0.19mL

9.60mL

1.92mL

0.96mL

19.21mL

3.84mL

1.92mL
参考文献

[1]Stoddart LA, Brown AJ, et al. Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S] thio)triphosphate binding studies reflects binding of an endogenous agonist. Mol Pharmacol. 2007 Apr;71(4):994-1005. Epub 2007 Jan 2.

[2]Briscoe CP, Peat AJ, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148(5):619-28.