Ulixacaltamide

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Chemical Structure| 1199236-64-0 同义名 : Z944; PRAX-944
CAS号 : 1199236-64-0
货号 : A751695
分子式 : C19H27ClFN3O2
纯度 : 99%+
分子量 : 383.89
MDL号 : MFCD27966181
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(130.25 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Calcium Channel

    hCaV3.2, IC50:110 nM

    hCaV3.1, IC50:50 nM
描述 Z944 is a T-type calcium channel antagonist potentially for the treatment of pain. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.60mL

0.52mL

0.26mL

13.02mL

2.60mL

1.30mL

26.05mL

5.21mL

2.60mL
参考文献

[1]Marks WN, Greba Q, et al. The T-type calcium channel antagonist Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats. Neuroscience. 2016 Sep 22;332:121-9.

[2]Tringham E, Powell KL, et al. T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci Transl Med. 2012 Feb 15;4(121):121ra19.