(E/Z)-GSK-3β inhibitor 1

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Chemical Structure| 3367-88-2 同义名 : -
CAS号 : 3367-88-2
货号 : A749708
分子式 : C14H10N2O
纯度 : 97%
分子量 : 222.24
MDL号 : MFCD00022808
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(224.98 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 (E/Z)-GSK-3β inhibitor 1 is a racemic mixture composed of the (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. It functions as an inhibitor of glycogen synthase kinase 3β (GSK-3β) and exhibits significant antidiabetic efficacy, with an IC50 value of 4.9 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.50mL

0.90mL

0.45mL

22.50mL

4.50mL

2.25mL

45.00mL

9.00mL

4.50mL
参考文献

[1]Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817.