BAY 41-2272
产品说明书
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同义名 : | - |
| CAS号 : | 256376-24-6 | |
| 货号 : | A749144 | |
| 分子式 : | C20H17FN6 | |
| 纯度 : | 99% | |
| 分子量 : | 360.39 | |
| MDL号 : | MFCD06411391 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 16 mg/mL(44.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | BAY 41-2272, an oral and soluble activator of guanylate cyclases (sGC), enhances sGC activity 400-fold in combination with NO. It effectively reduces cardiac workload and boosts cardiac output, making it suitable for cardiovascular disease research[1][2]. | ||
| 作用机制 | BAY 41-2272 binds to α1-subunit of sGC through Cys 238 and Cys 243.[1] | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.77mL 0.55mL 0.28mL |
13.87mL 2.77mL 1.39mL |
27.75mL 5.55mL 2.77mL |
| 参考文献 |
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