Guanidine HCl

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Chemical Structure| 50-01-1 同义名 : 盐酸胍 ;Guanidinium chloride; Aminoformamidine hydrochloride; Guanidine hydrochloride
CAS号 : 50-01-1
货号 : A741759
分子式 : CH6ClN3
纯度 : 98%
分子量 : 95.53
MDL号 : MFCD00013026
存储条件:

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(1099.12 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(1046.78 mM),配合低频超声助溶

生物活性
描述 Guanidine hydrochloride, a strong chaotropic agent, is known for its potent protein denaturing effects[1].[2].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00458952 Pheochromocytoma ... 展开 >> Paraganglioma 收起 << Phase 1 Phase 2 Completed - United States, New York ... 展开 >> New York Presbyterian Hospital-Weill Cornell Medical Center New York, New York, United States, 10021 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Rhode Island Rhode Island Hospital Providence, Rhode Island, United States, 02903 收起 <<
NCT00458952 - Completed - -
NCT03658902 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

10.47mL

2.09mL

1.05mL

52.34mL

10.47mL

5.23mL

104.68mL

20.94mL

10.47mL

参考文献

[1]Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231(2):180-4.

[2]Saeed Emadi, et al. A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation. Biochem Biophys Res Commun. 2014 Aug 8;450(4):1339-44.

[3]G Jung, et al. Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol. 2001 Jul;43(1):7-10.

[4]E C Herrmann Jr, et al. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982 Dec;2(6):339-46.