GYY4137

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Chemical Structure| 106740-09-4 同义名 : -
CAS号 : 106740-09-4
货号 : A736350
分子式 : C15H25N2O3PS2
纯度 : 98%
分子量 : 376.47
MDL号 : MFCD18428020
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(278.9 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 18 mg/mL(47.81 mM)，配合低频超声助溶
生物活性
描述 GYY4137 is a slow-release H2S donor with vasodilatory and antihypertensive activities. GYY4137 also exhibits anti-inflammatory and anticancer activities[1][2][3].In the concentration range of 400-800 μM, GYY4137 exhibited concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11, and U2OS) without affecting the survival of normal human lung fibroblasts (IMR90, WI-38)[2].In the concentration range of 0.1-0.5 mM, GYY4137 reduced LPS-induced production of nitrite (NO2), PGE2, TNF-α, and IL-6 in human synoviocytes (HFLS) and articular chondrocytes (HAC), decreased the levels and catalytic activities of inducible nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2), and reduced LPS induced NF-κB activation[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.28mL

2.66mL

1.33mL

26.56mL

5.31mL

2.66mL
参考文献

[1]Li L, et al. Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide. Circulation. 2008;117(18):2351-2360.

[2]Lee ZW, et al. The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One. 2011;6(6):e21077.

[3]Li L, et al. The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells. J Cell Mol Med. 2013;17(3):365-376.

[4]Lu S, Gao Y, et al. GYY4137, a hydrogen sulfide (H₂S) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. Int J Oncol. 2014;44(4):1259-1267.

[5]Hou X, et al. GYY4137, an H2S Slow-Releasing Donor, Prevents Nitrative Stress and α-Synuclein Nitration in an MPTP Mouse Model of Parkinson's Disease. Front Pharmacol. 2017;8:741. Published 2017 Oct 30.