Cercosporamide

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Chemical Structure| 131436-22-1 同义名 : (-)-Cercosporamide
CAS号 : 131436-22-1
货号 : A733926
分子式 : C16H13NO7
纯度 : 98+%
分子量 : 331.28
MDL号 : MFCD22683839
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Cercosporamide is a potent and selective Mnk inhibitor, and an orally bioavailable antifungal agent, suppresses phosphorylation of eIF4E and exhibits antileukemic effects.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.02mL

0.60mL

0.30mL

15.09mL

3.02mL

1.51mL

30.19mL

6.04mL

3.02mL
参考文献

[1]Altman JK, Szilard A, et al. Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors. Blood. 2013 May 2;121(18):3675-81.

[2]Sussman A, Huss K, et al. Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot Cell. 2004 Aug;3(4):932-43.