PRT062607

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Chemical Structure| 1370261-96-3 同义名 : P505-15; BIIB-057; PRT-2607
CAS号 : 1370261-96-3
货号 : A728509
分子式 : C19H23N9O
纯度 : 99%
分子量 : 393.45
MDL号 : MFCD23105961
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 PRT062607 is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM with > 80-fold selectivity for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.54mL

0.51mL

0.25mL

12.71mL

2.54mL

1.27mL

25.42mL

5.08mL

2.54mL
参考文献

[1]Spurgeon SE, Coffey G, et al. The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia. J Pharmacol Exp Ther. 2013 Feb;344(2):378-87.

[2]Coffey G, DeGuzman F, et al. Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis. J Pharmacol Exp Ther. 2012 Feb;340(2):350-9.