(E/Z)-CP-724714

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Chemical Structure| 537705-08-1 同义名 : CP-724714
CAS号 : 537705-08-1
货号 : A725977
分子式 : C27H27N5O3
纯度 : 95%
分子量 : 469.54
MDL号 : MFCD19687281
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
靶点

  • HER2/ErbB2

    HER2/ErbB2, IC50:10 nM

  • HER2

    HER2/ErbB2, IC50:10 nM
描述 CP-724714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, > 640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc in cell-free assays.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.65mL

2.13mL

1.06mL

21.30mL

4.26mL

2.13mL
参考文献

[1]Feng B, Xu JJ, et al. Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714. Toxicol Sci. 2009 Apr;108(2):492-500.

[2]Jani JP, Finn RS, et al. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res. 2007 Oct 15;67(20):9887-93.