LP-533401

产品说明书

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Chemical Structure| 945976-43-2 同义名 : -
CAS号 : 945976-43-2
货号 : A724867
分子式 : C27H22F4N4O3
纯度 : 99%+
分子量 : 526.49
MDL号 : MFCD19053188
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut. LP-533401 completely inhibits serotonin production in Tph1–expressing cells (RBL2H3 cells) at a dose of 1 μM[1].
作用机制 LP-533401 interacts with two amino acids, Tyr235 and Phe241, near Tph1 catalytic site. [2]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.50mL

1.90mL

0.95mL

18.99mL

3.80mL

1.90mL
参考文献

[1]Yadav, V.K., et al. Inhibition of gut-derived serotonin synthesis: A potential bone anabolic treatment. Nat. Med. 16(3), 308-312 (2010).

[2]Abid S, et al. Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303(6):L500-8.

[3]Krevvata M, et al. Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts. Blood. 2014 Oct 30;124(18):2834-46.