PTP1B-IN-4

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Chemical Structure| 765317-72-4 同义名 : PTP1B Inhibitor; Protein Tyrosine Phosphatase 1B Inhibitor; 1T4J; NUN17724; PTP1B inhibitor 2; PTP1B-IN-2; FRJ
CAS号 : 765317-72-4
货号 : A719591
分子式 : C26H19Br2N3O7S3
纯度 : 96%
分子量 : 741.45
MDL号 : N/A
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(141.61 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 PTP1B-IN-4 is a non-competitive allosteric inhibitor for the enzyme protein tyrosine phosphatase PTP1B, exhibiting an inhibitory concentration (IC50) value of 8 μM. This compound is considered promising for studies related to obesity and diabetes[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.35mL

0.27mL

0.13mL

6.74mL

1.35mL

0.67mL

13.49mL

2.70mL

1.35mL
参考文献

[1]Wiesmann, C., et al. Allosteric inhibition of protein tyrosine phosphatase 1B. Nature Structural & Molecular Biology, 2004. 11(8), 730–737.

[2]Jin, T., et al. Selective binding modes and allosteric inhibitory effects of lupane triterpenes on protein tyrosine phosphatase 1B. Scientific Reports, 2016. 6(1).