Isoindigo

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Chemical Structure| 476-34-6 同义名 : Isoindigotin
CAS号 : 476-34-6
货号 : A711843
分子式 : C16H10N2O2
纯度 : 98%
分子量 : 262.26
MDL号 : MFCD00423577
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(95.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Isoindigo inhibits proliferation in various leukemia and cancer cell lines, displaying anticancer activity. Isoindigo and its derivatives may also bind the aryl hydrocarbon receptor (AhR). Additionally, similar compounds show chemotherapeutic benefits in animal models of leukemia.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.81mL

0.76mL

0.38mL

19.07mL

3.81mL

1.91mL

38.13mL

7.63mL

3.81mL
参考文献

[1]McClay K, Wan B, et al. A novel combinatorial biocatalytic approach for producing antibacterial compounds effective against Mycobacterium tuberculosis (TB). Appl Microbiol Biotechnol. 2013 Aug;97(16):7151-63.

[2]Wu KM, Zhang MY, et al. [Potential antileukemic agents, synthesis of derivatives of indirubin, indigo, and isoindigotin] . Yao Xue Xue Bao. 1985 Nov;20(11):821-6.