M2698

产品说明书

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Chemical Structure| 1379545-95-5 同义名 : MSC2363318A
CAS号 : 1379545-95-5
货号 : A711494
分子式 : C21H19ClF3N5O
纯度 : 99%+
分子量 : 449.86
MDL号 : MFCD31744446
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(266.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 M2698, an oral, ATP-competitive inhibitor, selectively targets p70S6K and Akt with IC50s of 1 nM for both p70S6K and Akt1/3. It is capable of crossing the blood-brain barrier and exhibits anti-cancer properties. At concentrations ranging from 0.3 nM to 50 M over 72 hours, M2698 dose-dependently curbs the proliferation of breast tumor cell lines, with IC50s between 0.02-8.5 µM. Additionally, at 0.3 and 1 µM for 24 hours, it inhibits p70S6K activity, triggers feedback phosphorylation on Akt, and reduces Akt activity in these cell lines. M2698 indirectly inhibits pGSK3β (IC50=17 nM) and pS6 (IC50=15 nM)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.11mL

2.22mL

1.11mL

22.23mL

4.45mL

2.22mL
参考文献

[1]Machl A, et al. M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. Am J Cancer Res. 2016 Mar 15;6(4):806-18.