R1530

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Chemical Structure| 882531-87-5 同义名 : -
CAS号 : 882531-87-5
货号 : A708136
分子式 : C18H14ClFN4O
纯度 : 98%
分子量 : 356.78
MDL号 : MFCD23704870
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(140.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • FGFR1

    FGFR1, IC50:28 nM
描述 R1530 is the multikinase inhibitor with potential antiangiogenesis and antineoplastic activities.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.80mL

0.56mL

0.28mL

14.01mL

2.80mL

1.40mL

28.03mL

5.61mL

2.80mL
参考文献

[1]Kolinsky K, Tovar C, et al. Preclinical evaluation of the novel multi-targeted agent R1530. Cancer Chemother Pharmacol. 2011 Dec;68(6):1585-94.

[2]Tovar C, Higgins B, et al. Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy. Cell Cycle. 2010 Aug 15;9(16):3364-75.