Levamlodipine

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Chemical Structure| 103129-82-4 同义名 : （S）-氨氯地平 ;(S)-Amlodipine; Levoamlodipine; S-amlodipine
CAS号 : 103129-82-4
货号 : A707253
分子式 : C20H25ClN2O5
纯度 : 98%
分子量 : 408.88
MDL号 : MFCD09832686
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(256.8 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Calcium Channel
描述 Levamlodipine is a calcium channel blocker drug. Levamlodipine (LEE) is a drug commonly used for antihypertensive treatment in clinical therapy[2]. Combined use of levamlodipine and bisoprolol produced better protection against stroke[3]. A single dose of levamlodipine (from 1 mg/kg), bisoprolol (from 0.125 mg/kg), and their combinations significantly decreased blood pressure. The levamlodipine-induced tachycardia and the bisoprolol-induced bradycardia were temporized by the combination of these two drugs. Levamlodipine and bisoprolol produce synergic effects on blood pressure reduction and organ protection in SHR(spontaneously hypertensive rats) [4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.45mL

0.49mL

0.24mL

12.23mL

2.45mL

1.22mL

24.46mL

4.89mL

2.45mL
参考文献

[1]Jain R, et al. Polyaniline-graphene oxide nanocomposite sensor for quantification of calcium channel blocker levamlodipine. Mater Sci Eng C Mater Biol Appl. 2016 Aug 1;65:205-14.

[2]Liu Z, Huang X, Jiang Z, Tuo X. Investigation of the binding properties between levamlodipine and HSA based on MCR-ALS and computer modeling. Spectrochim Acta A Mol Biomol Spectrosc. 2021 Jan 15;245:118929

[3]Gui H, Guo YF, Liu X, Zhang JM, Yang YL, Huang GZ, Liu JG. Effects of combination therapy with levamlodipine and bisoprolol on stroke in rats. CNS Neurosci Ther. 2013 Mar;19(3):178-82

[4]Yang YL, Yu LT, Wu ZT, Yu JG, Zhang JM, Chen QH, Bao YC, Liu JG. Synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats. CNS Neurosci Ther. 2012 Jun;18(6):471-4