Alisporivir

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Chemical Structure| 254435-95-5 同义名 : Debio-025; DEB-025; UNIL 025; UNII-VBP9099AA6
CAS号 : 254435-95-5
货号 : A704776
分子式 : C63H113N11O12
纯度 : 98+%
分子量 : 1216.64
MDL号 : MFCD28411375
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(41.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Alisporivir is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.82mL

0.16mL

0.08mL

4.11mL

0.82mL

0.41mL

8.22mL

1.64mL

0.82mL
参考文献

[1]Phillips S, Chokshi S, et al. Alisporivir inhibition of hepatocyte cyclophilins reduces HBV replication and hepatitis B surface antigen production. Gastroenterology. 2015 Feb;148(2):403-14.e7.

[2]Grise H, Frausto S, et al. A conserved tandem cyclophilin-binding site in hepatitis C virus nonstructural protein 5A regulates Alisporivir susceptibility. J Virol. 2012 May;86(9):4811-22.