Theliatinib

产品说明书

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Chemical Structure| 1353644-70-8 同义名 : 席栗替尼 ;Xiliertinib; HMPL-309; xiliertinibum
CAS号 : 1353644-70-8
货号 : A696645
分子式 : C25H26N6O2
纯度 : 99%
分子量 : 442.51
MDL号 : MFCD32173988
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(9.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • EGFR/ErbB1

    WT EGFR, IC50:3 nM

  • mutant EGFR

    EGFR T790M/L858R, IC50:22 nM
描述 Theliatinib, is a small molecule, epidermal growth factor receptor tyrosine kinase inhibitor with potential antineoplastic and anti-angiogenesis activities.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.26mL

0.45mL

0.23mL

11.30mL

2.26mL

1.13mL

22.60mL

4.52mL

2.26mL
参考文献

[1]Ren Y, Zheng J, et al. Anti-tumor efficacy of theliatinib in esophageal cancer patient-derived xenografts models with epidermal growth factor receptor (EGFR) overexpression and gene amplification. Oncotarget. 2017 Apr 19.