PD150606

产品说明书

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Chemical Structure| 179528-45-1 同义名 : -
CAS号 : 179528-45-1
货号 : A686967
分子式 : C9H7IO2S
纯度 : 98%
分子量 : 306.12
MDL号 : MFCD00949076
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(98 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.27mL

0.65mL

0.33mL

16.33mL

3.27mL

1.63mL

32.67mL

6.53mL

3.27mL
参考文献

[1]Squier MK, Sehnert AJ, et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999 Mar;178(3):311-9.

[2]Waters SL, Sarang SS, et al. Calpains mediate calcium and chloride influx during the late phase of cell injury. J Pharmacol Exp Ther. 1997 Dec;283(3):1177-84.