DM1

产品说明书

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Chemical Structure| 139504-50-0 同义名 : Maytansinoid DM 1; Mertansine; UNII-DDZ29HGH0E; DM1 [Maytansinoid]; DM1 Compound; Maytansinoid DM1
CAS号 : 139504-50-0
货号 : A686559
分子式 : C35H48ClN3O10S
纯度 : 99%+
分子量 : 738.29
MDL号 : MFCD28398157
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(81.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Mertansine (DM1) serves as a microtubulin inhibitor and is a maytansinoid designed for conjugation to antibodies to form antibody-drug conjugates (ADCs), aimed at reducing systemic toxicity associated with maytansine and improving tumor-specific delivery[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.35mL

0.27mL

0.14mL

6.77mL

1.35mL

0.68mL

13.54mL

2.71mL

1.35mL
参考文献

[1]Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.

[2]Lopus M. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett. 2011 Aug 28;307(2):113-8.

[3]Zhong P, et al. cRGD-installed docetaxel-loaded mertansine prodrug micelles: redox-triggered ratiometric dual drug release and targeted synergistic treatment of B16F10 melanoma. Nanotechnology. 2017 Jul 21;28(29):295103.