NU1025

产品说明书

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Chemical Structure| 90417-38-2 同义名 : NSC 696807
CAS号 : 90417-38-2
货号 : A672161
分子式 : C9H8N2O2
纯度 : 98%
分子量 : 176.17
MDL号 : MFCD00942555
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(596.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • PARP

    PARP, IC50:400 nM
描述 NU1025 is a potent PARP inhibitor with IC50 of 400 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.68mL

1.14mL

0.57mL

28.38mL

5.68mL

2.84mL

56.76mL

11.35mL

5.68mL
参考文献

[1]Kaundal RK, Shah KK, Sharma SS. Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. Life Sci. 2006 Nov 10;79(24):2293-302.

[2]Bowman KJ, Newell DR, et al. Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro. Br J Cancer. 2001 Jan 5;84(1):106-12.