Sinensetin

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Chemical Structure| 2306-27-6 同义名 : 甲基化黄酮 ;Pedalitin permethyl ether
CAS号 : 2306-27-6
货号 : A672073
分子式 : C20H20O7
纯度 : 95%
分子量 : 372.37
MDL号 : MFCD00017421
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(67.14 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Sinensetin is a methylated flavone found in certain citrus fruits. Sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels in adipocytes[3]. Sin (Sinensetin) may inhibit chondrocyte apoptosis induced by tert-butyl hydroperoxide (TBHP); at the same time, it might also inhibit the production of MMP13 and promote the production of aggrecan and collagen II. Sin promotes chondrocyte autophagy by activating AMPK/mTOR signaling pathway[4]. SIN significantly induced cell death in HepG2 cells, whereas the proliferation rate of Thle2, human liver epithelial cells, was unaffected by SIN[5]. Sinensetin has potential capacity to attenuate IAV (influenza A virus)-triggered pro-inflammatory response via inactivation of NF-κB, ERK1/2 MAPK and p38 MAPK signalings[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.43mL

2.69mL

1.34mL

26.86mL

5.37mL

2.69mL
参考文献

[1]Kang SI, Shin HS, Kim SJ. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38(4):552-8.

[2]Laavola M, Nieminen R, et al. Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation. Planta Med. 2012 May;78(8):779-86.

[3]Kang SI, Shin HS, Kim SJ. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38(4):552-8

[4]Zhou W, Shi Y, Wang H, Yu C, Zhu H, Wu A. Sinensetin Reduces Osteoarthritis Pathology in the Tert-Butyl Hydroperoxide-Treated Chondrocytes and the Destabilization of the Medial Meniscus Model Mice via the AMPK/mTOR Signaling Pathway. Front Pharmacol. 2021 Jul 16;12:713491

[5]Kim SM, Ha SE, Lee HJ, Rampogu S, Vetrivel P, Kim HH, Venkatarame Gowda Saralamma V, Lee KW, Kim GS. Sinensetin Induces Autophagic Cell Death through p53-Related AMPK/mTOR Signaling in Hepatocellular Carcinoma HepG2 Cells. Nutrients. 2020 Aug 15;12(8):2462

[6]Li J, Jie X, Liang X, Chen Z, Xie P, Pan X, Zhou B, Li J. Sinensetin suppresses influenza a virus-triggered inflammation through inhibition of NF-κB and MAPKs signalings. BMC Complement Med Ther. 2020 May 5;20(1):135