MKT-077

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Chemical Structure| 147366-41-4 同义名 : FJ-776
CAS号 : 147366-41-4
货号 : A670986
分子式 : C21H22ClN3OS2
纯度 : 95%
分子量 : 432.0
MDL号 : MFCD00953420
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 55 mg/mL(127.31 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, demonstrates significant antitumor activity[1]. MKT-077 displays low cytotoxicity, inhibiting a wide range of human cancer cell lines including colon cancer, breast cancer, and pancreatic cancer. It also impedes tumor growth in a nude mice engraftment tumor model. Its excitation/emission wavelengths are 488/543 nm[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.31mL

0.46mL

0.23mL

11.57mL

2.31mL

1.16mL

23.15mL

4.63mL

2.31mL
参考文献

[1]Starenki D, et al. Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo. Endocrinol Metab (Seoul). 2015 Dec;30(4):593-603.

[2]Li X, et al. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14;4(11)..