Y-320

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Chemical Structure| 288250-47-5 同义名 : -
CAS号 : 288250-47-5
货号 : A657468
分子式 : C27H29ClN6O2
纯度 : 99%+
分子量 : 505.01
MDL号 : MFCD28099803
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(7.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Y-320, a potent phenylpyrazoleanilide immunomodulator, is recognized for its oral activity. It suppresses IL-17 production by CD4 T cells stimulated with IL-15, presenting IC50 values ranging from 20 to 60 nM. This compound also bolsters TP53, DMD, and COL17A1 PTC readthrough alongside G418, elevating both cellular protein levels and protein synthesis. When used with a low dosage of Paclitaxel, Y-320 notably increases the sensitivity of multidrug resistance (MDR) tumors to the drug, triggering G2/M phase arrest and apoptosis. Y-320's applications extend to rheumatoid arthritis (RA) and cancer research[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.98mL

0.40mL

0.20mL

9.90mL

1.98mL

0.99mL

19.80mL

3.96mL

1.98mL
参考文献

[1]Ushio H, et, al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17.

[2]Hosseini-Farahabadi S, et, al. Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough. PLoS Biol. 2021 May 3;19(5):e3001221.

[3]Hong J, et, al. Y-320, a novel immune-modulator, sensitizes multidrug-resistant tumors to chemotherapy. Am J Transl Res. 2020 Feb 15;12(2):551-562.