Bavisant

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Chemical Structure| 929622-08-2 同义名 : JNJ-31001074
CAS号 : 929622-08-2
货号 : A653792
分子式 : C19H27N3O2
纯度 : 99%
分子量 : 329.44
MDL号 : MFCD19443732
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(318.73 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Bavisant is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.18mL

3.04mL

1.52mL

30.35mL

6.07mL

3.04mL
参考文献

[1]Weisler RH, Pandina GJ, et al. Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34.

[2]Hudkins RL, Raddatz R, et al. Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy] phenyl}-2H-pyridazin-3-one(CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. J Med Chem. 2011 Jul 14;54(13):4781-92.