ZM323881 HCl

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Chemical Structure| 193000-39-4 同义名 : ZM 323881 (hydrochloride); ZM323881 hydrochloride
CAS号 : 193000-39-4
货号 : A652756
分子式 : C22H19ClFN3O2
纯度 : 98%
分子量 : 411.86
MDL号 : MFCD08703130
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(121.4 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • VEGFR2

    VEGFR2, IC50:<2 nM
描述 ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor with IC50 of < 2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.43mL

0.49mL

0.24mL

12.14mL

2.43mL

1.21mL

24.28mL

4.86mL

2.43mL
参考文献

[1]Endo A, Fukuhara S, et al. Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J Recept Signal Transduct Res. 2003;23(2-3):239-54.

[2] Whittles CE, Pocock TM, et al. ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation. 2002 Dec;9(6):513-22.