Miquelianin

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Chemical Structure| 22688-79-5 同义名 : Quercetin 3-O-glucuronide; Quercetin 3-glucuronide; Quercituron; Mikwelianin; Q3GA; Quercetin 3-O-β-D-glucuronide
CAS号 : 22688-79-5
货号 : A651797
分子式 : C21H18O13
纯度 : 98%
分子量 : 478.36
MDL号 : MFCD09752939
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(62.71 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Miquelianin demonstrates antioxidant properties in human plasma, significantly reducing the consumption of lycopene, β-carotene, and α-tocopherol at 50 μM [1]. Miquelianin can penetrate the central nervous system from the small intestine [2]. Miquelianin significantly lowers the production of β-amyloid (Aβ) peptides in primary neuron cultures from the Tg2576 AD mouse model and disrupts the initial protein-protein interactions necessary for forming neurotoxic Aβ oligomers [3]. 0.1 μM miquelianin reduces ROS generation, cAMP and RAS activation, ERK1/2 phosphorylation, and expression of HMOX1, MMP2, and MMP9 genes. It inhibits invasion and MMP-9 induction in MDA-MB-231 breast cancer cells, as well as the binding of [3H]-NA to b2-AR, potentially acting as a dietary chemopreventive agent for stress-related breast cancer by modulating b2-adrenergic signaling [4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.45mL

2.09mL

1.05mL

20.90mL

4.18mL

2.09mL
参考文献

[1]Terao J, e al. Protection by quercetin and quercetin 3-O-beta-D-glucuronide of peroxynitrite-induced antioxidant consumption in human plasma low-density lipoprotein. Free Radic Res. 2001 Dec;35(6):925-31.

[2]Juergenliemk G, et al. In vitro studies indicate that miquelianin (quercetin 3-O-beta-D-glucuronopyranoside) is able to reach the CNS from the small intestine. Planta Med. 2003 Nov;69(11):1013-7.

[3]Butterweck V, et al. Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test. Planta Med. 2000 Feb;66(1):3-6.

[4]Yamazaki S, et al. Quercetin-3-O-glucuronide inhibits noradrenaline-promoted invasion of MDA-MB-231 human breast cancer cells by blocking β-adrenergic signaling. Arch Biochem Biophys. 2014 Sep 1;557:18-27.