AZD-3463

产品说明书

Print
Chemical Structure| 1356962-20-3 同义名 : ALK/IGF1R inhibitor
CAS号 : 1356962-20-3
货号 : A649749
分子式 : C24H25ClN6O
纯度 : 99%
分子量 : 448.95
MDL号 : MFCD25976759
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(40.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • ALK

    ALK, Ki:0.75 nM
描述 AZD3463 is an orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.14mL

2.23mL

1.11mL

22.27mL

4.45mL

2.23mL
参考文献

[1]Wang Y, Wang L, et al. Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. Sci Rep. 2016 Jan 20;6:19423.