Thalidomide-O-amido-PEG-C2-NH2

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Chemical Structure| 2022182-59-6 同义名 : -
CAS号 : 2022182-59-6
货号 : A648712
分子式 : C19H22N4O7
纯度 : 99%
分子量 : 418.4
MDL号 : MFCD31812169
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Thalidomide-O-amido-PEG-C2-NH2 is a crafted E3 ligase ligand-linker conjugate, integrating a Thalidomide-based cereblon ligand with a linker utilized in PROTAC technology[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.39mL

0.48mL

0.24mL

11.95mL

2.39mL

1.20mL

23.90mL

4.78mL

2.39mL
参考文献

[1]Chessum NEA, et al. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766). J Med Chem. 2018 Feb 8;61(3):918-933.