Litronesib

产品说明书

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Chemical Structure| 910634-41-2 同义名 : LY2523355
CAS号 : 910634-41-2
货号 : A647852
分子式 : C23H37N5O4S2
纯度 : 98%
分子量 : 511.7
MDL号 : MFCD19442197
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(97.71 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Litronesib is a selective, allosteric inhibitor of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.95mL

0.39mL

0.20mL

9.77mL

1.95mL

0.98mL

19.54mL

3.91mL

1.95mL
参考文献

[1]Wakui H, Yamamoto N, et al. A phase 1 and dose-finding study of LY2523355 (litronesib), an Eg5 inhibitor, in Japanese patients with advanced solid tumors. Cancer Chemother Pharmacol. 2014 Jul;74(1):15-23.