HT-2157

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Chemical Structure| 303149-14-6 同义名 : SNAP 37889
CAS号 : 303149-14-6
货号 : A645564
分子式 : C21H13F3N2O
纯度 : 98+%
分子量 : 366.34
MDL号 : MFCD30537225
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(81.89 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 HT-2157 is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.73mL

0.55mL

0.27mL

13.65mL

2.73mL

1.36mL

27.30mL

5.46mL

2.73mL
参考文献

[1]Ash BL, Zanatta SD, et al. The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats. Regul Pept. 2011 Jan 17;166(1-3):59-67.

[2]Swanson CJ, Blackburn TP, et al. Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94.