LDN-212320

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Chemical Structure| 894002-50-7 同义名 : OSU-0212320; LDN-0212320; LDN-0212320 Maleate
CAS号 : 894002-50-7
货号 : A637035
分子式 : C17H15N3S
纯度 : 99%+
分子量 : 293.39
MDL号 : MFCD05960679
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(170.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 LDN-212320 functions as an activator for the glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) at the translational level. It alleviates nociceptive pain through the upregulation of astroglial GLT-1 expression in the hippocampus and anterior cingulate cortex (ACC)[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.41mL

0.68mL

0.34mL

17.04mL

3.41mL

1.70mL

34.08mL

6.82mL

3.41mL
参考文献

[1]Ghallab Alotaibi, et al. Effects of glial glutamate transporter activator in formalin-induced pain behaviour in mice. Eur J Pain. 2019 Apr;23(4):765-783.

[2]Xuechao Xing, et al. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5774-7.