SRI-011381

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Chemical Structure| 1629138-41-5 同义名 : -
CAS号 : 1629138-41-5
货号 : A636073
分子式 : C20H31N3O
纯度 : 99%+
分子量 : 329.48
MDL号 : MFCD01475985
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(151.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SRI-011381, an orally active agonist of TGF-β signaling, demonstrates neuroprotective effects[1][2]. SRI-011381, at a concentration of 10 μM, enhances the proliferation of mouse lung fibroblasts and notably elevates the expression of TGF-β1, NALP3, collagen-1, and α-SMA[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.18mL

3.04mL

1.52mL

30.35mL

6.07mL

3.04mL
参考文献

[1]Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978.

[2]Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499.