CBL0137

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Chemical Structure| 1197996-80-7 同义名 : Curaxin 137; CBL-C137
CAS号 : 1197996-80-7
货号 : A632251
分子式 : C21H24N2O2
纯度 : 99%+
分子量 : 336.43
MDL号 : MFCD18071578
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 CBL0137 is a suppressor of the histone chaperone FACT, which is crucial for chromatin transcription. By downregulating NF-kappaB and activating p53, CBL0137 effectively reinstates acetylation and trimethylation of histone H3. Its role as an anticancer agent is further underscored by its ability to trigger apoptosis in cancer cells[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.97mL

0.59mL

0.30mL

14.86mL

2.97mL

1.49mL

29.72mL

5.94mL

2.97mL
参考文献

[1]Nature. 2022 Jun;606(7914):594-602. doi: 10.1038/s41586-022-04753-7. Epub 2022 May 25.

[2]Barone TA, et al. Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma. Neuro Oncol. 2017 Feb 1;19(2):186-196. h

[3]Burkhart C, et al. Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer. Oncotarget. 2014 Nov 30;5(22):11038-53.