Z-LLNle-CHO

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Chemical Structure| 133407-83-7 同义名 : GSII; Z-Leu-Leu-Nle-CHO; gamma-Secretase Inhibitor I. Z-Leu-Leu-Nle-CHO (Nle = Norleucine).
CAS号 : 133407-83-7
货号 : A631906
分子式 : C26H41N3O5
纯度 : 95%
分子量 : 475.62
MDL号 : MFCD02179375
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Z-LLNle-CHO is a γ-secretase inhibitor. Z-LLNle-CHO induces caspase- and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway and can be used in cancer research such as breast cancer and leukaemia[1][2].Z-LLNle-CHO caused inhibition of cell viability/proliferation in a dose-dependent manner in six breast cancer cell lines tested at concentrations of 0-5 µM. Z-LLNle-CHO has proteasome inhibitory activity and is cytotoxic to MCF-7 cells[1].Z-LLNle-CHO blocks the Akt-mediated pro-survival pathway and induces Caspase- and ROS-dependent apoptosis in Nalm6 and 697 cells[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.10mL

0.42mL

0.21mL

10.51mL

2.10mL

1.05mL

21.03mL

4.21mL

2.10mL
参考文献

[1]Han J, et al. The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition. Breast Cancer Res. 2009;11(4):R57.

[2]Meng X, et al. GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia. Leukemia. 2011 Jul;25(7):1135-46.