Sincalide
产品说明书
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同义名 : | CCK八肽硫酸盐 ;CCK-8; Cholecystokinin octapeptide; Kinevac; Cholecystokinin (26-33); CCK-8S; CCK Octapeptide (sulfated); CCK Octapeptide; SQ19844 |
| CAS号 : | 25126-32-3 | |
| 货号 : | A627742 | |
| 分子式 : | C49H62N10O16S3 | |
| 纯度 : | 98% | |
| 分子量 : | 1143.27 | |
| MDL号 : | MFCD00079849 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 50 mg/mL(43.73 mM)，配合低频超声，并调节pH至11 DMF: 50 mg/mL(43.73 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Sincalide is a rapid-acting, synthetic analog of cholecystokinin for intravenous use in postevacuation cholecystography[3]. Sincalide-stimulated cholescintigraphy is performed to quantify gallbladder contraction and emptying[4]. Sincalide antagonized the effect of morphine which inhibited the potentiation of ACh (Acetylcholine) on jejunal activities in vitro. The antagonistic effect of sincalide on morphine was mainly mediated by CCK-A receptor[5]. Sincalide (CCK-8) evoked guinea pig isolated ileum contraction at 10(-5)-10(-1) mumol/L in a concentration-dependent manner, EC50 being 207 pmol/L. It delayed the gastric emptying as well. The rate of inhibition of gastric emptying was 71 +/- 12% at 100 mg/kg by ip[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00737295 | Biliary Dyskinesia | Not Applicable | Terminated(PI left institution... 展开 >>, study interest wained-so stopped.) 收起 << | - | United States, Texas ... 展开 >> Texas Tech University Health Sciences Center Lubbock, Texas, United States, 79430 收起 << |
| NCT01656057 | To Assess the Impact of Bile A... 展开 >>cids on Human Glukagon-like-peptide-1 Secretion 收起 << | Not Applicable | Completed | - | Denmark ... 展开 >> University Hospital of Copenhagen, Gentofte Hospital, Diabetic Research Division Copenhagen, Hellerup, Denmark, 2900 收起 << |
| NCT02496221 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | United States, Maryland ... 展开 >> GSK Investigational Site Baltimore, Maryland, United States, 21225 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
0.87mL 0.17mL 0.09mL |
4.37mL 0.87mL 0.44mL |
8.75mL 1.75mL 0.87mL |
| 参考文献 |
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