PIK-293

产品说明书

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Chemical Structure| 900185-01-5 同义名 : -
CAS号 : 900185-01-5
货号 : A627101
分子式 : C22H19N7O
纯度 : 99%+
分子量 : 397.43
MDL号 : MFCD20272930
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(125.81 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • p110γ

    p110γ, IC50:10 μM

  • p110δ

    p110δ, IC50:0.24 μM
描述 PIK-293, a derivative of IC87114, functions as a PI3K inhibitor, with IC50 values of 0.24 μM, 10 μM, 25 μM, and 100 μM for p110δ, p110β, p110γ, and p110α isoforms, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.58mL

2.52mL

1.26mL

25.16mL

5.03mL

2.52mL
参考文献

[1]Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47.