Sonidegib diphosphate

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Chemical Structure| 1218778-77-8 同义名 : NVP-LDE225 diphosphate; Erismodegib diphosphate; Sonidegib; NVP-LDE225; Erismodegib; LDE225 (phosphate); LDE225 diphosphate
CAS号 : 1218778-77-8
货号 : A624949
分子式 : C26H32F3N3O11P2
纯度 : 99%+
分子量 : 681.49
MDL号 : MFCD16627994
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(154.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 LDE225 diphosphate is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.47mL

0.29mL

0.15mL

7.34mL

1.47mL

0.73mL

14.67mL

2.93mL

1.47mL
参考文献

[1]Irvine DA, Zhang B, et al. Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci Rep. 2016 May 9;6:25476.

[2]Pan S, Wu X, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med Chem Lett. 2010 Mar 16;1(3):130-4.