PF 750

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Chemical Structure| 959151-50-9 同义名 : -
CAS号 : 959151-50-9
货号 : A621847
分子式 : C22H23N3O
纯度 : 99%+
分子量 : 345.44
MDL号 : MFCD10567109
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(303.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 PF 750 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH), showing variable IC50 values ranging from 16.2 to 595 nM depending on different pre-incubation times. This variability highlights its covalent mechanism of action, specifically targeting and modifying the enzyme's active site serine nucleophile[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.89mL

0.58mL

0.29mL

14.47mL

2.89mL

1.45mL

28.95mL

5.79mL

2.89mL
参考文献

[1]Ahn K, et al. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry. 2007 Nov 13;46(45):13019-30.