Varlitinib

产品说明书

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Chemical Structure| 845272-21-1 同义名 : ARRY-334543; ASLAN001
CAS号 : 845272-21-1
货号 : A621686
分子式 : C22H19ClN6O2S
纯度 : 99%+
分子量 : 466.94
MDL号 : MFCD20275099
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(74.96 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • EGFR/ErbB1

    ErbB1, IC50:7 nM

  • HER2/ErbB2

    ErbB2, IC50:2 nM
描述 Varlitinib is a selective and potent ErbB1 (EGFR) and ErbB2 (HER2) inhibitor with IC50 of 7 nM and 2 nM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.14mL

0.43mL

0.21mL

10.71mL

2.14mL

1.07mL

21.42mL

4.28mL

2.14mL
参考文献

[1]Le Rhun E, Taillibert S, et al. Systemic therapy for recurrent meningioma. Expert Rev Neurother. 2016 Aug;16(8):889-901.

[2]Cross DA, Ashton SE, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4(9):1046-61.