ML-290

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Chemical Structure| 1482500-76-4 同义名 : -
CAS号 : 1482500-76-4
货号 : A621519
分子式 : C24H21F3N2O5S
纯度 : 98%
分子量 : 506.49
MDL号 : MFCD28118984
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(236.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 ML290 is a biased allosteric agonist at the relaxin receptor RXFP1 possessing a signalling profile indicative of vasodilator and anti-fibrotic properties.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.97mL

0.39mL

0.20mL

9.87mL

1.97mL

0.99mL

19.74mL

3.95mL

1.97mL
参考文献

[1]Kocan M, Sarwar M, et al. ML290 is a biased allosteric agonist at the relaxin receptor RXFP1. Sci Rep. 2017 Jun 7;7(1):2968.

[2]Diepenhorst NA, Petrie EJ, et al. Investigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1). J Biol Chem. 2014 Dec 12;289(50):34938-52.