Wilforine

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Chemical Structure| 11088-09-8 同义名 : WR
CAS号 : 11088-09-8
货号 : A620428
分子式 : C43H49NO18
纯度 : 98+%
分子量 : 867.85
MDL号 : MFCD01726768
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(57.61 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Wilforine is a natural product isolated and purified from the vines of Tripterygium wilfordii, with insecticidal activity by inhibiting the Na+-K+-ATPase in the central nervous system, and anti-inflammatory effect, which might be mediated by down-regulation of the expression of inflammatory factors TNF-α,IL-6 and NO.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.15mL

0.23mL

0.12mL

5.76mL

1.15mL

0.58mL

11.52mL

2.30mL

1.15mL
参考文献

[1]Su MX, Song M, et al. Application of a sensitive and specific LC-MS/MS method for determination of wilforine from Tripterygium wilfordii Hook. F. in rat plasma for a bioavailability study. Biomed Chromatogr. 2015 Jul;29(7):1042-7.

[2]Zhu C, Miao G, et al. Establishment of Tripterygium wilfordii Hook. f. Hairy root culture and optimization of its culture conditions for the production of triptolide and wilforine. J Microbiol Biotechnol. 2014 Jun 28;24(6):823-34.