Allitinib

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Chemical Structure| 897383-62-9 同义名 : ALS 1306; Ast-1306
CAS号 : 897383-62-9
货号 : A618188
分子式 : C24H18ClFN4O2
纯度 : 99%
分子量 : 448.87
MDL号 : MFCD17215204
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
靶点

  • EGFR/ErbB1

    EGFR, IC50:0.5 nM

  • HER2/ErbB2

    ErbB2, IC50:3.0 nM

  • ErbB4

    ErbB4, IC50:0.8 nM
描述 AST-1306 is an irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.14mL

2.23mL

1.11mL

22.28mL

4.46mL

2.23mL
参考文献

[1]Zhang H, Wang YJ, et la. AST1306, a potent EGFR inhibitor, antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Cancer Lett. 2014 Aug 1;350(1-2):61-8.

[2]Xie H, Lin L, et al. AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. PLoS One. 2011;6(7):e21487.