A-770041

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Chemical Structure| 869748-10-7 同义名 : -
CAS号 : 869748-10-7
货号 : A610293
分子式 : C34H39N9O3
纯度 : 98%
分子量 : 621.73
MDL号 : MFCD24873124
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(40.21 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 A-770041 is selective and orally active Src-family Lck inhibitor and is a 147 nM inhibitor of Lck(1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.61mL

0.32mL

0.16mL

8.04mL

1.61mL

0.80mL

16.08mL

3.22mL

1.61mL
参考文献

[1]Burchat A, Borhani DW, et al. Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection. Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10.

[2]Stachlewitz RF, Hart MA, et al. A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection. J Pharmacol Exp Ther. 2005 Oct;315(1):36-41. Epub 2005 Jul 12.