Scoulerine

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Chemical Structure| 6451-73-6 同义名 : (-)-Scoulerine; Discretamine; (S)-Scoulerine; l-Scoulerine; (–)-Scoulerine
CAS号 : 6451-73-6
货号 : A604632
分子式 : C19H21NO4
纯度 : 98%
分子量 : 327.37
MDL号 : MFCD00221721
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(320.73 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Scoulerine, a natural product isolated and purified from the herbs of Corydalis dubia., shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.31mL

15.27mL

3.05mL

1.53mL

30.55mL

6.11mL

3.05mL
参考文献

[1]Chlebek J, Doskocil I, et al. Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types. Nat Prod Commun. 2016 Jun;11(6):753-6.

[2]Wangchuk P, Keller PA, et al. Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia. J Ethnopharmacol. 2012 Aug 30;143(1):310-3.