ML329
产品说明书
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同义名 : | - |
| CAS号 : | 19992-50-8 | |
| 货号 : | A604604 | |
| 分子式 : | C16H12N2O4S | |
| 纯度 : | 98% | |
| 分子量 : | 328.34 | |
| MDL号 : | MFCD30579194 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 4 mg/mL(12.18 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO DMF: 5 mg/mL(15.23 mM)，配合低频超声助溶 |
| 生物活性 | |||
|---|---|---|---|
| 描述 | MITF (micropthalmia-associated transcription factor) is a lineage restricted basic helix-loop-helix leucine zipper transcription factor that is essential for melanocyte development, function and survival. TRPM-1 (melastatin) is one of the target gene of MITF. ML329 is a selective MITF with IC50 value of 1.2μM in a TRPM-1 promoter activity assay. ML329 exhibited selective anti-proliferative effect on MITF-dependent cells, SK-MEL-5 and MALME-3M, but not A375 cells which is a MITF-independent cell line. Treatment with ML329 reduced reduced the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.05mL 0.61mL 0.30mL |
15.23mL 3.05mL 1.52mL |
30.46mL 6.09mL 3.05mL |
| 参考文献 |
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[1]Faloon PW, Bennion M, et al. A Small Molecule Inhibitor of the MITF Molecular Pathway. |