Amsilarotene

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Chemical Structure| 125973-56-0 同义名 : TAC-101; Am 555S
CAS号 : 125973-56-0
货号 : A603641
分子式 : C20H27NO3Si2
纯度 : 95%
分子量 : 385.6
MDL号 : MFCD00952173
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(272.3 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Amsilarotene (TAC-101; Am 555S), a synthetic orally active retinoid, selectively binds to retinoic acid receptor α (RAR-α) with dissociation constants of 2.4 and 400 nM for RAR-α and RAR-β, respectively. It promotes apoptosis in cells of human gastric cancer, hepatocellular carcinoma, and ovarian carcinoma, and is useful for cancer research[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.97mL

2.59mL

1.30mL

25.93mL

5.19mL

2.59mL
参考文献

[1]Sun SY, et al. Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells. Cancer Res. 1997 Nov 1;57(21):4931-9.

[2]Suzuki N, et al. A novel retinoid, 4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid (TAC-101), induces apoptosis of human ovarian carcinoma cells and shows potential as a new antitumor agent for clear cell adenocarcinoma. Gynecol Oncol. 2004 Sep;94(3):

[3]Fujimoto K, et al. Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells. Int J Cancer. 1999 May 17;81(4):637-44.