Cephalomannine

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Chemical Structure| 71610-00-9 同义名 : NSC 318735; Baccatin III; Cephalomannine, taxol B.
CAS号 : 71610-00-9
货号 : A602084
分子式 : C45H53NO14
纯度 : 98%
分子量 : 831.9
MDL号 : MFCD01075131
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(126.22 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Cephalomannine is an alkaloidal analog of Paclitaxel, derived from various Cephalotaxus species. It functions as an orally active anti-tumor agent and is employed in chemotherapy for cancer research[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.20mL

0.24mL

0.12mL

6.01mL

1.20mL

0.60mL

12.02mL

2.40mL

1.20mL
参考文献

[1]Feng Gao, et al. Synthesis, isolation, stereostructure and cytotoxicity of paclitaxel analogs from cephalomannine.Fitoterapia. 2013 Oct;90:79-84.

[2]Jianhua Li, et al. Microbial transformation of cephalomannine by Luteibacter sp. J Nat Prod. 2007 Dec;70(12):1846-9.

[3]Ullah, Asmat et al. Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1α interaction in lung cancer. Cell death & disease vol. 2021;12(5):490.