TBHQ

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Chemical Structure| 1948-33-0 同义名 : 叔丁基对苯二酚（TBHQ） ;tert-Butylhydroquinone
CAS号 : 1948-33-0
货号 : A598680
分子式 : C10H14O2
纯度 : 99%
分子量 : 166.21
MDL号 : MFCD00002344
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 55 mg/mL(330.89 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 TBHQ, known as tert-Butylhydroquinone, is commonly employed as an Nrf2 activator and offers protection from cardiotoxicity caused by Doxorubicin (DOX) by stimulating Nrf2[1]. Additionally, TBHQ serves as an ERK activator and counteracts the inhibitory effect on cell proliferation in melanoma induced by Dehydrocorydaline (DHC)[2]. TBHQ, when used alone at concentrations ranging from 0 to 100 μM over 48 hours, does not compromise the viability of H9c2 cells. However, a 24-hour pre-treatment with TBHQ at varying concentrations significantly bolsters the viability of H9c2 cells, which otherwise diminishes in response to ethanol in a dose-responsive manner. Furthermore, TBHQ treatment notably improves the survival of H9c2 cardiomyocytes challenged with ethanol. Additionally, a brief 15-minute exposure to 5 μM TBHQ substantially curtails the number of apoptotic cells in H9c2 cells subjected to ethanol. Moreover, pre-treating H9c2 cells with 5 μM TBHQ significantly hampers the ethanol-triggered upsurge in caspase-3 and Bax levels, while concurrently elevating Bcl-2 expression[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.02mL

1.20mL

0.60mL

30.08mL

6.02mL

3.01mL

60.16mL

12.03mL

6.02mL
参考文献

[1]Lin-Feng Wang, et al. Tert-butylhydroquinone ameliorates doxorubicin-induced cardiotoxicity by activating Nrf2 and inducing the expression of its target genes. Am J Transl Res. 2015; 7(10): 1724–1735.

[2]XIAOJING SHI, et al. Tert-butylhydroquinone attenuates the ethanol-induced apoptosis of and activates the Nrf2 antioxidant defense pathway in H9c2 cardiomyocytes.Int J Mol Med. 2016 Jul; 38(1): 123–130.

[3]Hu H, et al. Dehydrocorydaline inhibits cell proliferation, migration and invasion via suppressing MEK1/2-ERK1/2 cascade in melanoma.Onco Targets Ther. 2019 Jul 2;12:5163-5175.

[4]Sukumari-Ramesh S, et al. Post-Injury Administration of Tert-butylhydroquinone Attenuates Acute Neurological Injury AfterIntracerebral Hemorrhage in Mice.J Mol Neurosci. 2016 Apr;58(4):525-31.