360A iodide

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Chemical Structure| 737763-37-0 同义名 : -
CAS号 : 737763-37-0
货号 : A595989
分子式 : C27H23I2N5O2
纯度 : 98+%
分子量 : 703.31
MDL号 : -
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(2.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 360A iodide is a strong affinity and selectivity inhibitor of G-quadruplex structures.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.42mL

0.28mL

0.14mL

7.11mL

1.42mL

0.71mL

14.22mL

2.84mL

1.42mL
参考文献

[1]Gauthier LR, Granotier C, et al. Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cell Mol Life Sci. 2012 Feb;69(4):629-40.

[2]Pennarun G, Granotier C, et al. Role of ATM in the telomere response to the G-quadruplex ligand 360A. Nucleic Acids Res. 2008 Mar;36(5):1741-54.