I-CBP112

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Chemical Structure| 1640282-31-0 同义名 : -
CAS号 : 1640282-31-0
货号 : A594660
分子式 : C27H36N2O5
纯度 : 98+%
分子量 : 468.59
MDL号 : MFCD26792587
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(64.02 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

1M HCl: 100 mg/mL(213.41 mM)，配合低频超声，并调节pH至1
生物活性
靶点

  • p300/CBP

    CBP, Kd:151 nM

    p300, Kd:167 nM
描述 I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor, that targets the CBP/p300 bromodomains.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.67mL

2.13mL

1.07mL

21.34mL

4.27mL

2.13mL
参考文献

[1]Zucconi BE, Luef B, et al. Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112. Biochemistry. 2016 Jul 12;55(27):3727-34.

[2]Picaud S, Fedorov O, et al. Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy. Cancer Res. 2015 Dec 1;75(23):5106-5119.